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. 2011 Apr;162(8):1686–1699. doi: 10.1111/j.1476-5381.2010.01174.x

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British Journal of Pharmacology © 2011 The British Pharmacological Society

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Concentration-dependent effect in wild-type (WT) and mtDNA-depleted (Rho) Hepa 1–6 mouse hepatoma cells of incubation with glycoursodeoxycholic acid (GUDCA) (A,D,G), glycochenodeoxycholic acid (GCDCA) (B,E,H) or paracetamol (C,F,I) for 48 h on Mdr1 (A,B,C), Mrp1 (D,E,F) and Mrp4 (G,H,I) expression as revealed by determining the abundance of mRNA using real-time quantitative RT-PCR. Values are expressed as mean ± SEM from five cultures measured in triplicate for each data point. *P < 0., significant differences between treated and untreated cells.

Concentration-dependent effect in wild-type (WT) and mtDNA-depleted (Rho) Hepa 1–6 mouse hepatoma cells of incubation with glycoursodeoxycholic acid (GUDCA) (A,D,G), glycochenodeoxycholic acid (GCDCA) (B,E,H) or paracetamol (C,F,I) for 48 h on Mdr1 (A,B,C), Mrp1 (D,E,F) and Mrp4 (G,H,I) expression as revealed by determining the abundance of mRNA using real-time quantitative RT-PCR. Values are expressed as mean ± SEM from five cultures measured in triplicate for each data point. *P < 0., significant differences between treated and untreated cells.