Figure 9.

Concentration-dependent effect in wild-type (WT) and mtDNA-depleted (Rho) Hepa 1–6 mouse hepatoma cells of the incubation with glycoursodeoxycholic acid (GUDCA), glycochenodeoxycholic acid (GCDCA) or paracetamol for 48 h on Fxr, Shp, Pxr and Nrf2 expression as revealed by determining the abundance of mRNA using real-time quantitative RT-PCR. Values are expressed as mean ± SEM from five cultures measured in triplicate for each data point. *P < 0.05, significantly different from untreated cells.