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Schematic representation of the mechanisms proposed to be involved in the Shp and Nrf2-mediated up-regulation of ABC proteins induced by bile acids and paracetamol in liver cells. ARE, antioxidant response element; Fxr, farnesoid nuclear receptor; Keap1, Kelch-like ECH-associated protein 1; Maf, musculo-aponeurotic fibrosarcoma protein; ROS, reactive oxygen species; Shp, small heterodimer partner.
