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. 2011 Apr;162(8):1757–1769. doi: 10.1111/j.1476-5381.2010.01186.x

Figure 7.

Figure 7

Pregnenolone sulphate-mediated insulin secretion is inhibited by mefenamic acid. INS-1E cells were cultured and insulin secretion measured as described in Methods. Test substances were added as indicated. (A) The effect of pregnenolone sulphate and mefenamic acid in the presence of 100 µM tolbutamide. (B) The effect of pregnenolone sulphate and mefenamic acid on insulin secretion induced by 12 mM glucose. Data are means ± SEM of three independent experiments. ***P < 0.001 to 0.5 mM glucose; +++P < 0.001 to 5 mM glucose; ##P < 0.005 and ###P < 0.001 to the respective condition without mefenamic acid; §P < 0.05 and §§P < 0.005 to the respective condition without pregnenolone sulphate; ns, not significant.