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. 2011 Apr;162(8):1884–1893. doi: 10.1111/j.1476-5381.2011.01201.x

Figure 6.

Figure 6

Effects of zaprinast on 8-nitro-cGMP or 8-bromo-cGMP-induced relaxation in db/db aorta contracted by Phe. Cumulative concentration–relaxation curves to 8-nitro-cGMP (A) or 8-bromo-cGMP (B) of the Phe-contracted aortas from db/db mice (n = 4–6 for each group). Zaprinast (1 µM) was added 30 min before the addition of Phe. (C) Comparison of the relaxation responses to 8-nitro-cGMP (100 µM) and 8-bromo-cGMP (100 µM) induced in the presence and absence of zaprinast in db/db aortic rings contracted by Phe. Data are shown as mean ± SEM. *P < 0.05 versus control.