TABLE 2.
Cardiopulmonary test parameters of HD patients, presymptomatic HD subjects, and healthy controls
| Symptomatic HD patients | Presymptomatic HD subjects | Controls | ||
|---|---|---|---|---|
| Wpeak (Watts) | 111.7 ± 37.6; (75–200) | 165.0 ± 39.4; (125–225) | 158.7 ± 45.8; (100–250) | P = 0.003 s-HD vs C |
| Peak VO2/kg (mL/Kg/min) | 23.4 ± 6.7; (14.4–39.1) | 29.5 ± 7.0; (19.6–42.2) | 28.8 ± 6.0; (19.7–47.5) | P = 0.026 s-HD vs C |
| Peak VO2/kg (% of theorethical) | 75.7 ± 22.3; (42–125) | 78.7 ± 21.1; (53–113) | 83.3 ± 14.7; (60–129) | |
| Heart rate peak (beats/min) | 145.6 ± 19.4; (106–180) | 156.3 ± 11.0; (139–176) | 154.3 ± 18.9; (112–185) | |
| RQ (peak) adimensional ratio | 1.0 ± 0.1; (1.0–1.1) | 1.1 ± 0.1; (0.9–1.3) | 1.1 ± 0.2; (0.9–1.7) | |
| O2 pulse peak (mL/beat) | 11.3 ± 4.2; (5.8–20.4) | 13.5 ± 3.7; (8.2–18.3) | 13.4 ± 3.5; (6.9–18.8) | |
| O2 pulse peak (%) | 84.5 ± 19.7; (49–128) | 93.1 ± 19.0; (73–135) | 100.0 ± 21.6; (62–140) | |
| VD/VT (%) | 97.3 ± 36.5; (57–187) | 72.6 ± 17.6; (40–92) | 66.5 ± 19.4; (30–104) | |
| VE/VCO2 adimensional ratio | 32.0 ± 2.9; (27–36) | 30.1 ± 4.3; (24–38) | 29.9 ± 3.2; (26–36) | |
| AT VO2 (mL/Kg/min) | 13.3 ± 2.5; (9.7–19.0) | 13.6 ± 3.3; (9.8–20.3) | 19.0 ± 5.0; (11.9–33.1) | P = 0.000125 s-HD vs C |
| P = 0.000125 preHD vs C | ||||
| AT (%) | 38.9 ± 7.3; (27–50) | 35.3 ± 8.0; (26–56) | 54.7 ± 13.1; (39–88) | P = 0.000251 s-HD vs C |
| P = 0.000166 preHD vs C | ||||
| AT (Watts) | 38.3 ± 12.9; (25–50) | 57.5 ± 16.9; (25–75) | 99.0 ± 43.0; (50–200) | P = 0.000002 s-HD vs C |
| P = 0.000002 preHD vs C |
Data are expressed as mean ± SD; (range). Not reported statistical scores were P > 0.05.