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Acquisition and treatment of the TMA double labeled by immunofluorescence for p53 and HIPK2. A: Low-resolution acquisition of the overall TMA. B: Confocal microscopy acquisition of three fluorescent signals: DAPI (nuclear staining), p53 (green Alexa 488), and HIPK2 (red Alexa 594) of a single core. C: Operator-guided microdissection of images to eliminate stromal component. D: Segmentation and threshold-based cell scoring.
