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. 2011 May;178(5):1986–1998. doi: 10.1016/j.ajpath.2011.01.021

Figure 3.

Figure 3

Effect of p53 mutations on p53 expression, survival, and expression of p53 targets. A: Repartition of the TP53 mutations among mutated cases. Fifty-four mutations were observed among 51 mutated cases (69%). Three cases showed two mutations: a missense mutation along with another missense mutation, a nonsense mutation, or a silent mutation. B: Percentage of p53-positive cells in the WT, mutated, and missense p53 tumor groups. C and D: Survival analysis according to p53 mutational status: survival of the WT p53 tumors versus the p53 mutated group (C) or the tumor group bearing a missense p53 mutation (D). E and F: Variation of the expression of Bax and p21 in the WT and mutated (mut) p53 groups of tumors, evaluated by quantitative RT-PCR: Bax FC and percentage of tumors that respectively have a decreased, invariant (inv), or increased expression of Bax (E) or p21 FC and percentage of tumors that respectively have a decreased, inv, or increased expression of p21 (F).