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. 2011 May;178(5):2416–2423. doi: 10.1016/j.ajpath.2011.01.013

Figure 1.

Figure 1

IL-1β expression in laser-induced neovascularization. IL-1β real-time PCR in retina (A) and choroid (B) and VEGF real-time PCR in retina (C) and choroid (D) at different time points in laser-induced CNV in the eye cup of C57BL/6 mice (control n = 4 eyes, 1 hour n = 8 eyes, 6 hours n = 7 eyes, 20 hours n = 5 eyes, 72 hours n = 4 eyes; one-way analysis of variance *P = 0.03 (A and B). Representative micrographs of IHC of uninjured (E–H), 10 hours (I–L), and 72 hours (M–P) of laser-injured choroid/RPE flatmounts (n = 4 mice per time point). IL-1β staining (green staining E, I, and M), Ly6G staining (red staining F, J, and N), Iba1 staining (blue staining G, K, and O) merged photographs (H, L, and P). Scale bars = 50 μm (E–P). Arrowheads: Iba1-positive cells (K and O).