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. 2011 May;178(5):2416–2423. doi: 10.1016/j.ajpath.2011.01.013

Figure 3.

Figure 3

IL-1β induces vascular sprouting in aortic rings. Confocal microscopic image of IL-1RI (green staining A) and Collagen IV IHC (red staining B, merge C) of the laser-injury site at day 5 (n = 3 mice) of C57BL/6 mice. Photographs of aortic rings at day 4, 24 hours after incubation with control (D), IL-1β (E), IL-1Ra (F), or IL-1β and IL-1Ra (G). H: Measurements of the area of vascular sprouting in the presence of control (n = 6), IL-1β (n = 12), IL-1Ra (n = 6), or IL-1β and IL-1Ra (n = 6). I: Measurements of the area of vascular sprouting in the presence of control (n = 6), IL-1β (n = 12), soluble VEGFR1 (n = 5) or IL-1β and soluble VEGFR1 (n = 6). *P < 0.05 one-way analysis of variance. Scale bars: (A–C) = 50 μm; (D–G) = 350 μm.