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. 2011 May;178(5):2416–2423. doi: 10.1016/j.ajpath.2011.01.013

Figure 4.

Figure 4

IL-1 and light- and laser-induced injury. Histology of the photoreceptor cell layer at 100 μm of the laser injury in PBS- (A; n = 3 mice) and IL-1R– (B; n = 4 mice) treated C57BL/6 mice. Quantification of number of rows of photoreceptor nuclei at increasing distance from the injury site in PBS- and IL-1Ra–treated animals (C). Real-time PCR of IL-1β expression in Wistar eye cup mRNA extracts (D; control n = 4, 1 hour n = 5, 12 hours n = 5). Normal light-raised Wistar rats (E); light-injured PBS-treated (F; n = 4) and light-injured IL-1Ra–treated (G; n = 6) eyes. Quantification of number of rows of photoreceptor nuclei at different distances from the optic nerve measured on oriented sections, crossing the inferior pole, optic nerve, and superior pole (H). *P = 0.0003. Scale bars: A and B = 50 μm; E–G = 20 μm. ONL, outer nuclear layer; INL, inner nuclear layer; RPE, retinal pigment epithelium; CHO, choroid; CT, control.