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Patterns of BBB disruption detected by fibrinogen IHC. A: Fibrinogen extravasation occurs in association with ruptured capillaries and RHs. B: Fibrinogen has extravasated across a microvessel occluded by thrombus. C and D: Increased permeability of the BBB to fibrinogen in microvessels with heavy iRBC sequestration occurs without thrombosis or hemorrhage in the white (C) and gray (D) matter. Scale bar = 50 μm (A–D).
