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. 2011 May;178(5):2224–2235. doi: 10.1016/j.ajpath.2011.01.054

Figure 3.

Figure 3

CNM features observed in RW-DNM2 mice. A: Immediately after dissection TA muscles were weighed from mice 2 and 4 weeks PI. Graph represents TA weight as a percentage of total body weight (n = 3 to 6 mice). B: HE-stained transversal sections from D and F were analyzed for fiber area (n = 3 to 5 mice). C: Transverse muscle sections were analyzed for fiber area. Fiber size is grouped into 200-μm intervals and represented as the percentage of total fibers in each group (n = 5 mice, 4 weeks PI). D: Transverse TA sections from AAV-transduced GFP, WT-DNM2, or RW-DNM2 mice 2 weeks PI (2wPI) stained with HE (top) or SDH (bottom) and viewed by light microscopy. Scale bar = 50 μm. E: The frequency of fibers with internal or central nuclei 2wPI were scored (n = 3 to 5 mice). Internal nuclei are defined as neither subsarcolemmal nor central. F: Transverse muscle sections 4 weeks PI (4wPI). Higher magnification (zoom) images are shown. Scale bar = 50 μm. G: Nuclear position; 4wPI (n = 5 to 6 mice). All graphs depict mean ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001).