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. 2011 May;178(5):2224–2235. doi: 10.1016/j.ajpath.2011.01.054

Figure 6.

Figure 6

Altered T-tubule structures in RW-DNM2 mice. TA muscles from AAV-transduced GFP, WT-DNM2, or RW-DNM2 mice 2 (A) and 4 (B) weeks PI imaged by TEM. Magnified (zoom) images shown on the right. SR, sarcoplasmic reticulum; T, T-tubule. Arrows: swollen sarcoplasmic reticulum; arrowhead: abnormal membrane structures near mitochondria. Scale bar = 0.2 μm. The shape factor was calculated from T-tubules shown in A and B. C: 2 weeks PI (2wPI). D: 4 weeks PI (4wPI). A shape factor of 1 = circle and 0 = straight line (shape factors for T-tubules in images in A and B are indicated). Graph represents mean ± SEM (***P < 0.001) (n = approximately 50 T-tubules per mouse for two mice per group).