Table 1.

Immune semaphorins, their receptors and diseases

Semaphorins/ receptors	Expression in the immune system	Binding partner	Immunological activities	Related-neurological diseases
Sema3A	N.D.	Plexin A proteins Neuropilin-1	Inhibition of monocyte migration Inhibition of T-cell activation	Alzheimer’s disease Atopic dermatitis
Sema4A	Dendritic cells Acticated-T cells Th1 cells	Plexin B proteins Plexin-D1 TIM-2	T-cell activation Promotion of Th1-differentiation	EAE Atopic dermatitis
Sema4D	T cells Activated-B cells Dendritic cells	Plexin-B1 CD72	B-cell activation DC-activation	EAE HAM
Sema5A	N.D. (Oligodendrocytes)	N.D.	N.D.	Parkinson’s disease
Sema6D	T cells B cells NK cells	Plexin-A1	DC-activation
Sema7A	Acticated-T cells	Plexin-C1 Integrin α1β1	Monocyte/macrophage-activation	Contact hypersensitivity EAE
Neuropilin-1	T cells Treg cells	Class III semaphorins		Alzheimer’s disease
Plexin-A1	Dendritic cells (Osteoclasts)	Class VI semaphorins	DC-activation	EAE
Plexin-A4	T cells Dendritic cells Macrophages	Class VI semaphorins	Inhibition of T-cell activation	EAE
Plexin-B1		Class IV semaphorins
TIM-2	Acticated-T cells Th2 cells	Sema4A	T-activation	EAE Airway atopy
CD72	B cells (Dendritic cells)	Sema4D	B-cell activation DC-activation
Integrin α1β1	Monocytes Macrophages	Sema7A	Monocyte/macrophage-activation	EAE