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. 2011 May;178(5):2275–2285. doi: 10.1016/j.ajpath.2011.01.030

Figure 8.

Figure 8

Tau-Y197 colocalizes partially with Tau-nY197, but fails to colocalize with a late tau marker of tangle evolution in AD. CIP-treated tissue sections from areas of the HP and ITG from severe AD samples (Braak stage VI) were labeled with Tau-Y197 and Tau-nY197. In all samples analyzed, Tau-Y197 colocalized partially with Tau-nY197 (A–C). However, extensive colocalization was observed with Tau-C3-positive aggregates that were present within neurons labeled with Tau-Y197 in controls (D–F). In severe AD (Braak stage VI), the fibrillar tau lesions labeled with Tau-Y197 also colocalized extensively with Tau-C3 (G–I). However, Tau-Y197 failed to colocalize in most instances with MN423 (J–L). Scale bars = 20 μm (all panels).