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Lung Mp load in SPLUNC1−/− and hSPLUNC1 transgenic mice. After 24 hours of infection, Mp load was quantified in lung tissue from C57BL/6 SPLUNC1−/− or SPLUNC1+/+ mice (n = 5 mice per group) (A) or FVB/n hSPLUNC1 transgene-positive (Tg+) or transgene-negative (Tg−) mice (n = 10 mice per group) (B). A and B, Data represent results obtained from three independent experiments. CFUs, colony-forming units. *P < 0.05.
