Table 3.
Banff Components in the Patient Biopsies That Were Diagnostic for TxG and the Two Preceding Biopsies, 1stPrevBx and 2ndPrevBx
|
n = 10 |
||||||
|---|---|---|---|---|---|---|
| 1stPrevBx |
2ndPrevBx |
DiagnBx |
||||
| PBx | CBx | PBx | CBx | PBx | CBx | |
| ai | 1.0 ± 0.82 | 0.8 ± 0.79 | 0.5 ± 0.71 | 0.4 ± 0.52 | 0.7 ± 0.48 | 1.0 ± 0.94 |
| at | 0.5 ± 0.97 | 0.4 ± 0.70 | 0.3 ± 0.48 | 0.3 ± 0.48 | 0.1 ± 0.32 | 0.4 ± 0.70 |
| av | 0.1 ± 0.32 | 0.1 ± 0.32 | 0.3 ± 0.67 | 0.1 ± 0.32 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| ag | 0.5 ± 1.08 | 0.0 ± 0.0 | 0.3 ± 0.48 | 0.3 ± 0.67 | 0.1 ± 0.32 | 0.0 ± 0.0 |
| ptc | 0.3 ± 0.67 | 0.0 ± 0.0 | 0.1 ± 0.32 | 0.0 ± 0.0 | 0.6 ± 0.84 | 0.0 ± 0.0 |
| ct | 0.7 ± 0.67 | 0.8 ± 0.79 | 0.4 ± 0.52 | 0.7 ± 0.48 | 1.3 ± 0.82 | 0.9 ± 0.32 |
| ci | 0.6 ± 0.70 | 0.9 ± 0.99 | 0.3 ± 0.48 | 0.5 ± 0.53 | 1.1 ± 0.99 | 0.6 ± 0.52 |
| cv | 0.2 ± 0.63 | 0.2 ± 0.63 | 0.1 ± 0.32 | 0.0 ± 0.0 | 0.2 ± 0.42 | 0.0 ± 0.0 |
| cg* | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.9 ± 0.99 | 0.0 ± 0.0 |
| mm* | 0.0 ± 0.0 | 0.3 ± 0.67 | 0.3 ± 0.48 | 0.3 ± 0.48 | 1.3 ± 0.67 | 0.7 ± 0.95 |
| ah | 0.1 ± 0.32 | 0.6 ± 0.97 | 0.7 ± 0.82 | 0.4 ± 0.70 | 0.7 ± 0.95 | 0.4 ± 0.70 |
| C4d peritubular | 0.4 ± 0.97 | 0.4 ± 0.84 | 0.6 ± 1.07 | 0.4 ± 0.84 | 0.6 ± 0.97 | 0.4 ± 0.84 |
| C4dglomerular | 0.8 ± 1.03 | 0.0 ± 0.0 | 0.9 ± 1.29 | 0.3 ± 0.95 | 0.7 ± 1.16 | 0.2 ± 0.63 |
Data shown include C4d staining of peritubular capillary endothelial cells and GECs. Glomerular endothelial C4d staining (C4dglomerular) is not among the presently described Banff components; it is defined in analogy to the C4d scoring in the peritubular capillaries. Components are shown in comparison to control biopsies (CBx) that were matched for time after transplantation. None of the components except for inclusion criteria cg and mm were different between the groups.
CBx, control biopsy; PBx, patient biopsy; ai, acute extent of interstitial infiltrate at severity of acute tubulitis; av, severity of acute endothelialitis; ag, severity of acute glomerulitis; ptc, severity of peritubular capillaritis; ct, extent of tubular atrophy; ci, extent of interstitial fibrosis; cv, severity of chronic transplant vasculopathy; cg, severity of transplant glomerulopathy; mm, extent of mesangial expansion; ah, severity of arteriolar hyalinosis.