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. 2011 May;178(5):2407–2415. doi: 10.1016/j.ajpath.2011.01.043

Table 2.

Univariate and Multivariate Analyses for Disease-Specific Survival

Univariate analysis
Multivariate analysis
Parameters Number of cases Number of events P value HR 95% CI P value
Sex
 Male 97 40 0.4239
 Female 1 0
Age (years)
 <60 85 37 0.2537
 ≥60 13 3
Primary tumor (T)
 T1-T2 49 10 0.0008 1 0.044
 T3 17 10 1.303 0.562–3.021
 T4 32 20 2.439 1.009–5.882
Nodal status (N)
 N0 38 9 0.0009 1 0.012
 N1 14 8 1.488 0.614–63.610
 N2 30 19 2.849 1.258–6.452
Extracapsular extension of metastatic node
 Present 20 12 0.2890
 Absent 32 18
Histological grade
 Well differentiated 61 22 0.2558
 Moderately differentiated 28 13
 Poorly differentiated 9 5
Vascular invasion
 Present 18 10 0.1461
 Absent 80 30
Perineurial invasion
 Present 26 14 0.1553
 Absent 72 26
Tumor necrosis
 Present 38 17 0.5545
 Absent 60 23
CIS at adjacent mucosa
 Present 24 12 0.2476
 Absent 74 28
Surgical margin
 Clear 91 37 0.9199
 Unclear 5 2
RSF-1 expression
 Low expression 44 3 <0.0001 1 0.001
 Overexpression 54 37 33.97 4.456–244.598

Follow-up duration ranged from 1 to 112 months; mean, 40.12; median, 45.

95% CI, 95% confidence interval; CIS, carcinoma in situ; HR, hazard ratio.

Statistically significant.