Table 2.
Univariate and Multivariate Analyses for Disease-Specific Survival
Univariate analysis |
Multivariate analysis |
|||||
---|---|---|---|---|---|---|
Parameters | Number of cases | Number of events | P value | HR | 95% CI | P value |
Sex | ||||||
Male | 97 | 40 | 0.4239 | |||
Female | 1 | 0 | ||||
Age (years) | ||||||
<60 | 85 | 37 | 0.2537 | |||
≥60 | 13 | 3 | ||||
Primary tumor (T) | ||||||
T1-T2 | 49 | 10 | 0.0008⁎ | 1 | 0.044⁎ | |
T3 | 17 | 10 | 1.303 | 0.562–3.021 | ||
T4 | 32 | 20 | 2.439 | 1.009–5.882 | ||
Nodal status (N) | ||||||
N0 | 38 | 9 | 0.0009⁎ | 1 | 0.012⁎ | |
N1 | 14 | 8 | 1.488 | 0.614–63.610 | ||
N2 | 30 | 19 | 2.849 | 1.258–6.452 | ||
Extracapsular extension of metastatic node | ||||||
Present | 20 | 12 | 0.2890 | |||
Absent | 32 | 18 | ||||
Histological grade | ||||||
Well differentiated | 61 | 22 | 0.2558 | |||
Moderately differentiated | 28 | 13 | ||||
Poorly differentiated | 9 | 5 | ||||
Vascular invasion | ||||||
Present | 18 | 10 | 0.1461 | |||
Absent | 80 | 30 | ||||
Perineurial invasion | ||||||
Present | 26 | 14 | 0.1553 | |||
Absent | 72 | 26 | ||||
Tumor necrosis | ||||||
Present | 38 | 17 | 0.5545 | |||
Absent | 60 | 23 | ||||
CIS at adjacent mucosa | ||||||
Present | 24 | 12 | 0.2476 | |||
Absent | 74 | 28 | ||||
Surgical margin | ||||||
Clear | 91 | 37 | 0.9199 | |||
Unclear | 5 | 2 | ||||
RSF-1 expression | ||||||
Low expression | 44 | 3 | <0.0001⁎ | 1 | 0.001⁎ | |
Overexpression | 54 | 37 | 33.97 | 4.456–244.598 |
Follow-up duration ranged from 1 to 112 months; mean, 40.12; median, 45.
95% CI, 95% confidence interval; CIS, carcinoma in situ; HR, hazard ratio.
Statistically significant.