Table 2.
Univariate and Multivariate Analyses for Disease-Specific Survival
| Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| Parameters | Number of cases | Number of events | P value | HR | 95% CI | P value |
| Sex | ||||||
| Male | 97 | 40 | 0.4239 | |||
| Female | 1 | 0 | ||||
| Age (years) | ||||||
| <60 | 85 | 37 | 0.2537 | |||
| ≥60 | 13 | 3 | ||||
| Primary tumor (T) | ||||||
| T1-T2 | 49 | 10 | 0.0008⁎ | 1 | 0.044⁎ | |
| T3 | 17 | 10 | 1.303 | 0.562–3.021 | ||
| T4 | 32 | 20 | 2.439 | 1.009–5.882 | ||
| Nodal status (N) | ||||||
| N0 | 38 | 9 | 0.0009⁎ | 1 | 0.012⁎ | |
| N1 | 14 | 8 | 1.488 | 0.614–63.610 | ||
| N2 | 30 | 19 | 2.849 | 1.258–6.452 | ||
| Extracapsular extension of metastatic node | ||||||
| Present | 20 | 12 | 0.2890 | |||
| Absent | 32 | 18 | ||||
| Histological grade | ||||||
| Well differentiated | 61 | 22 | 0.2558 | |||
| Moderately differentiated | 28 | 13 | ||||
| Poorly differentiated | 9 | 5 | ||||
| Vascular invasion | ||||||
| Present | 18 | 10 | 0.1461 | |||
| Absent | 80 | 30 | ||||
| Perineurial invasion | ||||||
| Present | 26 | 14 | 0.1553 | |||
| Absent | 72 | 26 | ||||
| Tumor necrosis | ||||||
| Present | 38 | 17 | 0.5545 | |||
| Absent | 60 | 23 | ||||
| CIS at adjacent mucosa | ||||||
| Present | 24 | 12 | 0.2476 | |||
| Absent | 74 | 28 | ||||
| Surgical margin | ||||||
| Clear | 91 | 37 | 0.9199 | |||
| Unclear | 5 | 2 | ||||
| RSF-1 expression | ||||||
| Low expression | 44 | 3 | <0.0001⁎ | 1 | 0.001⁎ | |
| Overexpression | 54 | 37 | 33.97 | 4.456–244.598 | ||
Follow-up duration ranged from 1 to 112 months; mean, 40.12; median, 45.
95% CI, 95% confidence interval; CIS, carcinoma in situ; HR, hazard ratio.
⁎
Statistically significant.