Table 1.
Correlation of UBE2C Copy Number with Clinicopathologic Parameters in CRC
| Total no. (%) | High UBE2C, no. (%) | Low UBE2C, no. (%) | P value | |
|---|---|---|---|---|
| Total no. of cases | 351 | 161 (45.9) | 190 (54.1) | |
| Age | ||||
| ≤50 years | 115 (32.8) | 54 (47.0) | 61 (53.0) | 0.7754 |
| >50 years | 236 (67.2) | 107 (45.3) | 129 (54.7) | |
| Sex | ||||
| Male | 170 (48.4) | 78 (45.9) | 92 (54.1) | 0.9961 |
| Female | 181 (51.6) | 83 (45.9) | 98 (54.1) | |
| Tumor site | ||||
| Descending colon | 292 (83.2) | 140 (48.0) | 152 (52.0) | 0.0801 |
| Ascending colon | 59 (16.8) | 21 (35.6) | 38 (64.4) | |
| Histologic type | ||||
| Adenocarcinoma | 305 (86.9) | 145 (47.5) | 160 (52.5) | 0.1024 |
| Mucinous carcinoma | 46 (13.1) | 16 (34.8) | 30 (65.2) | |
| Tumor stage | ||||
| I | 44 (13.2) | 23 (52.3) | 21 (47.7) | 0.3240 |
| II | 112 (33.5) | 44 (39.3) | 68 (60.7) | |
| III | 137 (41.0) | 68 (49.6) | 69 (50.4) | |
| IV | 41 (12.3) | 19 (46.3) | 22 (53.7) | |
| Differentiation | ||||
| Well | 27 (7.7) | 9 (33.3) | 18 (66.7) | 0.3523 |
| Moderate | 261 (74.4) | 124 (47.5) | 137 (52.5) | |
| Poor | 63 (17.9) | 28 (44.4) | 35 (55.6) | |
| Cyclin A⁎ | ||||
| High expression | 276 (81.2) | 136 (49.3) | 140 (50.7) | 0.0161 |
| Low expression | 64 (18.8) | 21 (32.8) | 43 (67.2) | |
| Cyclin B1⁎ | ||||
| High expression | 298 (87.4) | 149 (50.0) | 149 (50.0) | 0.0022 |
| Low expression | 43 (12.6) | 11 (25.6) | 32 (74.4) | |
| Ki-67⁎ | ||||
| High expression | 293 (85.9) | 141 (48.1) | 152 (51.9) | 0.0541 |
| Low expression | 48 (14.1) | 16 (33.3) | 32 (66.7) | |
| 5-year overall survival, % | 52.9 | 70.5 | 0.0267 |
⁎
Analysis failure of some IHC markers was attributed to missing or nonrepresentative spots.