Table 4.

Cox Regression Analysis for Overall Survival in the CRC Subset with Stage I and II Tumors

Clinical parameters	Univariate		Multivariate
	Risk ratio (95% CI)	P value	Risk ratio (95% CI)	P value
Age ≥50 years	1.17 (0.80 –1.74)	0.4306	1.37 (0.36 –6.62)	0.6550
Male sex	1.10 (0.76 –1.59)	0.6084	1.32 (0.41 –4.47)	0.6379
Grade 3 tumor (poorly differentiated)	1.41 (0.90 –2.14)	0.1307	0.78 (0.04 –4.77)	0.8199
MSI-S/L (stable/low)	2.04 (1.14 –4.05)	0.0149	2.78 (0.51 –52.0)	0.2770
UBE2C overexpression	3.35 (1.13 –11.1)	0.0291	3.67 (1.15 –14.03)	0.0276

CI, confidence interval; MSI, microsatellite instability status; S/L, stable/low [ie, not MSI-H (high)].