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. 2011 May;178(5):2205–2214. doi: 10.1016/j.ajpath.2011.01.044

Figure 1.

Figure 1

Effect of vorinostat on histone hyperacetylation in vitro and in vivo. A: Immunoblotting for total and acetylated histone H3 in lysates from human umbilical vein endothelial cells exposed to dimethyl sulfoxide or 10 μmol/L vorinostat for 24 hours. B–E: IHC for acetylated histone H3 with C57BL/6 + vehicle (B), C57BL/6 + vorinostat (C), STZ-C57BL/6 + vehicle (D), and STZ-C57BL/6 + vorinostat (E). F: Quantitation of acetylated histone H3–positive nuclei. *P < 0.01 versus C57BL/6 + vehicle; **P < 0.01 versus STZ-C57BL/6 + vehicle.