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. 2011 May;178(5):2205–2214. doi: 10.1016/j.ajpath.2011.01.044

Figure 4.

Figure 4

Oxidative-nitrosative stress in control and STZ-diabetic C57BL/6 mice treated with vehicle or vorinostat for 18 weeks. A and B: Immunoblotting for nitrotyrosine in kidney homogenates revealed the presence of an approximately 210-kDa protein band, the nitrosylation of which was increased with diabetes mellitus and reduced with vorinostat. C–F: Immunostaining for nitrotyrosine with C57BL/6 + vehicle (C), C57BL/6 + vorinostat (D), STZ-C57BL/6 + vehicle (E), and STZ-C57BL/6 + vorinostat (F). G: Urinary 8-OHdG excretion in control and diabetic mice treated with vehicle or vorinostat for 18 weeks. *P < 0.05 versus all other groups; **P < 0.001 versus C57BL/6 + vehicle; ***P < 0.05 versus STZ-C57BL/6 + vehicle. AU indicates arbitrary unit.