Table 1.

Functional Characteristics of Control and STZ-Diabetic C57BL/6 Mice Treated with Vehicle or Vorinostat for 18 Weeks

Treatment	B.wt. (g)	Systolic BP (mm Hg)	HbA1c (%)	Kidney wt. (g)	Kidney wt., b.wt. (%)	Albumin/creatinine ratio (μg/mg)
C57BL/6 + vehicle	30.1 ± 0.5	121 ± 4	4.9 ± 0.1	0.166 ± 0.005	0.55 ± 0.01	51.6 ×/÷ 1.1
C57BL/6 + vorinostat	28.2 ± 0.6	121 ± 3	4.7 ± 0.1	0.151 ± 0.003	0.54 ± 0.01	57.2 ×/÷ 1.2
STZ-C57BL/6 + vehicle	22.0 ± 1.3⁎	115 ± 4	12.8 ± 0.1⁎	0.216 ± 0.013⁎	0.98 ± 0.02⁎	128.5 ×/÷ 1.2†
STZ-C57BL/6 + vorinostat	20.5 ± 1.1	109 ± 3	12.6 ± 0.3	0.185 ± 0.005‡	0.91 ± 0.03	48.1 ×/÷ 1.3‡

Data are given as mean ± SEM.

BP, blood pressure.

^⁎P < 0.001 versus C57BL/6 + vehicle.

^†P < 0.05 versus C57BL/6 + vehicle.

^‡P < 0.05 versus STZ-C57BL/6 + vehicle.