Table 2.

Functional Characteristics of eNOS^–/– Mice Treated with Vehicle or Vorinostat for 18 Weeks

Treatment	B.wt. (g)	Systolic BP (mm Hg)	Serum creatinine ×10–1 (mg/dL)	HbA1c (%)	Kidney wt. (g)	Kidney wt., b.wt. (%)
eNOS–/– + vehicle	27.3 ± 0.6	133 ± 3	0.91 ± 0.08	4.9 ± 0.1	0.138 ± 0.004	0.50 ± 0.01
eNOS–/– + vorinostat	26.4 ± 0.6	135 ± 3	1.31 ± 0.11	4.7 ± 0.1	0.131 ± 0.003	0.50 ± 0.01
STZ-eNOS–/– + vehicle	20.4 ± 0.5⁎	110 ± 4⁎	2.50 ± 0.51†	12.5 ± 0.4⁎	0.186 ± 0.006⁎	0.91 ± 0.02⁎
STZ-eNOS–/– + vorinostat	18.8 ± 1.3	110 ± 3	2.27 ± 0.30	12.2 ± 0.4	0.152 ± 0.012‡	0.83 ± 0.04§

Data are given as mean ± SEM.

BP, blood pressure.

^⁎P < 0.001 versus eNOS^–/– + vehicle.

^†P < 0.01 versus eNOS^–/– + vehicle.

^‡P < 0.01 versus STZ-eNOS^–/– + vehicle.

^§P < 0.05 versus STZ-eNOS^–/– + vehicle.