Table 1.

Association of 24 SNPs of LOXL1 in Caucasian Patients with ES and Control Subjects

SNP	Chromosomal Position*	Minor Allele	Minor Allele Frequency			P†	Padjusted‡	Padjusted§	OR (95% CI)
			ES	EG	Controls
rs12914489	71974990	A	0.147	0.145	0.071	0.0006	0.017	0.04	2.27 (1.41–3.66)
rs8029844	71980525	T	0.031	0.035	0.028	0.76			1.14 (0.50–2.62)
rs55736920	71982067	T	0.173	0.167	0.136	0.15			1.33 (0.90–1.97)
rs34894704	71982575	A	0.133	0.130	0.202	0.0097			0.61 (0.41–0.89)
rs4886467	71985866	T	0.415	0.404	0.535	0.0008	0.22	0.96	0.62 (0.46–0.82)
rs62004863	71987041	C	0.111	0.120	0.068	0.034			1.71 (1.04–2.83)
rs12914677	71988982	G	0.368	0.367	0.460	0.009			0.68 (0.51–0.91)
rs4558370	71991963	T	0.080	0.074	0.162	0.0005	0.87	0.34	0.45 (0.28–0.71)
rs4461027	71998601	C	0.604	0.596	0.426	8.2 × 10−7	0.17	0.72	2.04 (1.54–2.78)
rs4886761	72002604	T	0.521	0.511	0.391	0.0002	0.25	0.72	1.70 (1.28–2.25)
rs8026259	72003812	C	0.247	0.269	0.196	0.082			1.35 (0.96–1.89)
rs16958477	72005519	A	0.580	0.573	0.403	6.4 × 10−7	0.60	0.47	2.05 (1.54–2.72)
rs1048661‖	72006599	T	0.160	0.153	0.271	0.0003	0.99	N/A	0.51 (0.35–0.74)
rs3825942‖	72006635	A	0.010	0.007	0.189	5.6 × 10−17	0.018	N/A	0.04 (0.02–0.12)
rs2165241‖	72009255	T	0.785	0.783	0.469	9.4 × 10−20	0.25	0.05	4.17 (3.03–5.56)
rs2304719	72022553	T	0.065	0.071	0.290	4.2 × 10−16	0.43	0.31	0.17 (0.11–0.27)
rs1530169	72024173	T	0.180	0.158	0.237	0.051			0.71 (0.50–1.00)
rs4243042	72028677	T	0.253	0.241	0.538	6.2 × 10−16	0.94	0.13	0.29 (0.21–0.39)
rs2304722	72028802	C	0.008	0.007	0.003	0.30			3.11 (0.32–30.04)
rs12437465	72030299	T	0.174	0.172	0.437	1.3 × 10−15	0.83	0.32	0.27 (0.20–0.38)
rs12441138	72030950	A	0.039	0.032	0.043	0.81			0.92 (0.45–1.86)
rs8818	72031331	C	0.171	0.167	0.236	0.026			0.67 (0.47–0.95)
rs7173049	72031663	G	0.130	0.123	0.231	0.0002	0.80	0.65	0.50 (0.34–0.72)
rs10152898	72042174	T	0.206	0.200	0.135	0.0099			1.66 (1.13–2.43)

^*Base pair position in NCBI build 36.3 (National Center for Biotechnology Information, Bethesda, MD).

^†χ² test. The Bonferroni corrected significance level was 0.0021 (0.05/24). Significant SNPs are highlighted in bold.

^‡Logistic regression after adjustment for age and all the other 12 significant SNPs. The Bonferroni corrected significance level was 0.0038 (0.05/13).

^§Logistic regression after adjusting for age, rs1048661 and rs3825942. The Bonferroni-corrected significance level was 0.0038 (0.05/13). N/A, not applicable.

^‖Significant association with ES has been reported in our previous study of a subgroup of samples.⁴