Table 2.

Haplotype Analysis of Six Significant SNPs in the Promoter Region of LOXL1

Haplotype*	Estimated Haplotype Frequency			P†	OR (95% CI)†
	ES	Controls	Combined
GGGCTA	0.337	0.237	0.286	0.002	1.64 (1.20–2.24)
GGGTCC	0.172	0.162	0.167	0.69	1.08 (0.74–1.58)
GTGTCC	0.098	0.222	0.161	2.3 × 10−6	0.38 (0.25–0.57)
ATGCTA	0.135	0.063	0.098	0.0008	2.34 (1.42–3.85)
GTTTCC	0.049	0.119	0.085	0.0005	0.39 (0.22–0.68)
Total	0.791	0.803	0.797	3.7 × 10−9‡

^*The six SNPs included in the haplotype analysis are rs12914489, rs4886467, rs4558370, rs4461027, rs4886761, and rs16958477. Only haplotypes with a frequency higher than 5% in the combined samples were shown.

^†Obtained from the haplotype-specific test using Haploview. The OR was calculated for each of individual haplotypes compared with all the other haplotypes. The Bonferroni-corrected significance level was 0.01 (0.05/5). Significant SNPs are highlighted in bold.

^‡Omnibus test with PLINK.