TABLE 2.
ASSOCIATIONS BETWEEN ESTRADIOL AND RIGHT VENTRICULAR MEASURES IN LIMITED AND ADJUSTED MODELS AMONG MEN AND WOMEN, BASED ON HORMONE THERAPY USE
| Men (n = 1,927) |
Women: HT Users (n = 567) |
Women: HT Nonusers (n = 1,140) |
||||
|---|---|---|---|---|---|---|
| β (95% CI)* | P Value | β (95% CI) | P Value | β (95% CI) | P Value | |
| RVEF, % | ||||||
| Limited† | −0.23 (−0.97 to 0.50) | 0.54 | 1.07 (0.49 to 1.65) | < 0.001 | 0.15 (−0.39 to 0.69) | 0.58 |
| Adjusted‡ | −0.26 (−1.00 to 0.48) | 0.49 | 0.91 (0.32 to 1.50) | 0.003 | 0.13 (−0.41 to 0.67) | 0.65 |
| Adjusted + LVEF | −0.35 (−1.02 to 0.32) | 0.30 | 0.88 (0.32 to 1.43) | 0.002 | 0.05 (−0.46 to 0.55) | 0.86 |
| RVSV, ml | ||||||
| Limited | −1.72 (−3.92 to 0.47) | 0.12 | 1.04 (−0.29 to 2.37) | 0.13 | −0.31 (−1.53 to 0.91) | 0.61 |
| Adjusted | −1.25 (−3.43 to 0.93) | 0.26 | 0.57 (−0.76 to 1.90) | 0.40 | −0.29 (−1.50 to 0.93) | 0.40 |
| RV mass, g | ||||||
| Limited | −0.16 (−0.60 to 0.29) | 0.49 | 0.08 (−0.20 to 0.37) | 0.57 | −0.25 (−0.51 to 0.01) | 0.06 |
| Adjusted | −0.08 (−0.53 to 0.37) | 0.72 | 0.02 (−0.27 to 0.30) | 0.90 | −0.24 (−0.50 to 0.02) | 0.07 |
| Adjusted + LV mass | −0.02 (−0.44 to 0.39) | 0.91 | 0.11 (−0.16 to 0.38) | 0.42 | −0.20 (−0.44 to 0.05) | 0.12 |
| RVEDV, ml | ||||||
| Limited | −2.21 (−5.20 to 0.76) | 0.15 | −0.08 (−1.83 to 1.67) | 0.93 | −0.71 (−2.31 to 0.89) | 0.38 |
| Adjusted | −1.47 (−4.44 to 1.50) | 0.33 | −0.50 (−2.26 to 1.25) | 0.57 | −0.64 (−2.24 to 0.96) | 0.43 |
| Adjusted + LVEDV | 1.17 (−1.03 to 3.38) | 0.30 | 0.17 (−1.13 to 1.47) | 0.80 | 0.57 (−0.62 to 1.76) | 0.35 |
| RVESV, ml | ||||||
| Limited | −0.49 (−1.99 to 1.01) | 0.52 | −1.12 (−1.99 to −0.26) | 0.01 | −0.40 (−1.19 to 0.39) | 0.32 |
| Adjusted | −0.22 (−1.73 to 1.29) | 0.77 | −1.07 (−1.94 to −0.21) | 0.02 | −0.36 (−1.15 to 0.44) | 0.38 |
| Adjusted + LVESV | 0.50 (−0.84 to 1.83) | 0.47 | −0.87 (−1.67 to −0.08) | 0.03 | 0.02 (−0.71 to 0.75) | 0.95 |
Definition of abbreviations: CI = confidence interval; HT = hormone therapy; LV = left ventricle; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; RV = right ventricle; RVEDV = right ventricular end-diastolic volume; RVEF = right ventricular ejection fraction; RVESV = right ventricular end-systolic volume; RVSV = right ventricular stroke volume.
Per ln(nmol/L) increase in estradiol.
Adjusted for age, race/ethnicity, height, weight, waist circumference.
Adjusted for age, race/ethnicity, height, weight, waist circumference, smoking (status and pack-years), diabetes mellitus, impaired glucose tolerance, hypertension, use of antihypertensive medications, systolic and diastolic blood pressure, cholesterol, high density lipoprotein levels, statin use, intentional exercise, and level of education.