TABLE 4.
ASSOCIATIONS BETWEEN DEHYDROEPIANDROSTERONE AND RIGHT VENTRICULAR MEASURES IN LIMITED AND ADJUSTED MODELS, BY SEX
| Men (n = 1,927) |
Women (n = 1,696) |
|||
|---|---|---|---|---|
| β (95% CI)* | P Value | β (95% CI) | P Value | |
| RVEF, % | ||||
| Limited† | −0.19 (−0.83 to 0.44) | 0.55 | −0.54 (−1.07 to −0.01) | 0.05 |
| Adjusted‡ | −0.19 (−0.82 to 0.45) | 0.56 | −0.54 (−1.08 to 0.00) | 0.05 |
| Adjusted + LVEF | −0.24 (−0.82 to 0.33) | 0.40 | −0.44 (−0.94 to 0.07) | 0.09 |
| RVSV, ml | ||||
| Limited | 0.16 (−1.73 to 2.05) | 0.87 | 0.77 (−0.42 to 1.97) | 0.21 |
| Adjusted | 0.55 (−1.32 to 2.42) | 0.56 | 1.37 (0.15 to 2.59) | 0.03 |
| RV mass, g | ||||
| Limited | 0.08 (−0.30 to 0.47) | 0.67 | 0.21 (−0.04 to 0.47) | 0.10 |
| Adjusted | 0.13 (−0.25 to 0.52) | 0.51 | 0.36 (0.10 to 0.62) | 0.01 |
| Adjusted + LV mass | 0.19 (−0.17 to 0.55) | 0.31 | 0.25 (0.00 to 0.49) | 0.05 |
| RVEDV, ml | ||||
| Limited | 0.87 (−1.69 to 3.43) | 0.51 | 2.00 (0.43 to 3.57) | 0.01 |
| Adjusted | 1.39 (−1.16 to 3.94) | 0.29 | 2.80 (1.20 to 4.40) | 0.001 |
| Adjusted + LVEDV | 1.30 (−0.59 to 3.19) | 0.18 | 2.28 (1.09 to 3.46) | <0.001 |
| RVESV, ml | ||||
| Limited | 0.71 (−0.57 to 2.00) | 0.28 | 1.23 (0.45 to 2.01) | 0.001 |
| Adjusted | 0.84 (−0.45 to 2.13) | 0.20 | 1.43 (0.63 to 2.22) | <0.001 |
| Adjusted + LVESV | 0.92 (−0.23 to 2.10) | 0.12 | 1.28 (0.55 to 2.00) | 0.001 |
Definition of abbreviations: CI = confidence interval; DHEA = dehydroepiandrosterone; LV = left ventricle; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; RV = right ventricle; RVEDV = right ventricular end-diastolic volume; RVEF = right ventricular ejection fraction; RVESV = right ventricular end-systolic volume; RVSV = right ventricular stroke volume.
Per ln(nmol/L) increase in DHEA.
Adjusted for age, race/ethnicity, height, weight, waist circumference, and DHEA supplementation.
Adjusted for age, race/ethnicity, height, weight, waist circumference, DHEA supplementation, smoking (status and pack-years), diabetes mellitus, impaired glucose tolerance, hypertension, use of antihypertensive medications, systolic and diastolic blood pressure, cholesterol, high density lipoprotein levels, statin use, intentional exercise, and level of education.