TABLE 5.
ASSOCIATIONS BETWEEN SEX HORMONE–BINDING GLOBULIN AND RIGHT VENTRICULAR MEASURES IN LIMITED AND ADJUSTED MODELS, BY SEX
| Men (n = 1,928) |
Women (n = 1,707) |
|||
|---|---|---|---|---|
| β (95% CI)* | P Value | β (95% CI) | P Value | |
| RVEF, % | ||||
| Limited† | 0.08 (−0.69 to 0.85) | 0.85 | 0.38 (−0.12 to 0.87) | 0.14 |
| Adjusted‡ | 0.12 (−0.68 to 0.91) | 0.78 | 0.20 (−0.34 to 0.75) | 0.47 |
| Adjusted + LVEF | 0.03 (−0.68 to 0.74) | 0.93 | 0.09 (−0.42 to 0.60) | 0.73 |
| RVSV, ml | ||||
| Limited | 1.96 (−0.34 to 4.25) | 0.09 | 1.16 (0.05 to 2.27) | 0.04 |
| Adjusted | 0.64 (−1.69 to 2.97) | 0.59 | 0.08 (−1.15 to 1.31) | 0.90 |
| RV mass, g | ||||
| Limited | 0.46 (−0.01 to 0.93) | 0.05 | 0.09 (−0.14 to 0.33) | 0.44 |
| Adjusted | 0.17 (−0.31 to 0.65) | 0.48 | −0.09 (−0.35 to 0.17) | 0.51 |
| Adjusted + LV mass | 0.16 (−0.28 to 0.61) | 0.47 | −0.03 (−0.28 to 0.21) | 0.78 |
| RVEDV, ml | ||||
| Limited | 2.90 (−0.20 to 6.01) | 0.07 | 1.03 (−0.43 to 2.50) | 0.17 |
| Adjusted | 0.78 (−2.40 to 3.95) | 0.63 | −0.18 (−1.80 to 1.44) | 0.83 |
| Adjusted + LVEDV | −0.13 (−2.47 to 2.22) | 0.92 | −0.42 (−1.62 to 0.77) | 0.49 |
| RVESV, ml | ||||
| Limited | 0.95 (−0.61 to 2.51) | 0.23 | −0.13 (−0.85 to 0.60) | 0.73 |
| Adjusted | 0.14 (−1.47 to 1.75) | 0.86 | −0.26 (−1.07 to 0.54) | 0.52 |
| Adjusted + LVESV | −0.07 (−1.49 to 1.36) | 0.93 | −0.09 (−0.82 to 0.65) | 0.82 |
Definition of abbreviations: CI = confidence interval; LV = left ventricle; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; RV = right ventricle; RVEDV = right ventricular end-diastolic volume; RVEF = right ventricular ejection fraction; RVESV = right ventricular end-systolic volume; RVSV = right ventricular stroke volume.
Per ln(nmol/L) increase in sex hormone–binding globulin.
Adjusted for age, race/ethnicity, height, weight, and waist circumference.
Adjusted for age, race/ethnicity, height, weight, waist circumference, smoking (status and pack-years), diabetes mellitus, impaired glucose tolerance, hypertension, use of antihypertensive medications, systolic and diastolic blood pressure, cholesterol, high density lipoprotein levels, statin use, intentional exercise, and level of education.