Table 1. CDR Sequence alignment of Herceptin and bH1 variants.
Light Chain | Heavy Chain | ||||||||||||||||||||||||||||||||||||
28 | 29 | 30 | 30a | 30b | 30c | 30d | 31 | 32 | 50 | 51 | 52 | 53 | 91 | 92 | 93 | 94 | 30 | 31 | 32 | 33 | 50 | 51 | 52 | 52a | 53 | 54 | 55 | 56 | 57 | 58 | 95 | 96 | 97 | 98 | 99 | 100 | |
Herceptin | D | V | N | . | . | . | . | T | A | S | A | S | F | H | Y | T | T | K | D | T | Y | R | I | Y | P | T | N | G | Y | T | R | W | G | G | D | G | F |
bH1 | I | P | R | S | I | S | G | Y | W | G | Y | ||||||||||||||||||||||||||
bH1-81 | N | I | A | K | T | I | S | G | Y | W | G | S | S | ||||||||||||||||||||||||
bH1-44 | N | I | A | K | T | I | S | G | Y | W | G | S | S | S | G | S | E | V | V |
Information tabulated based on [22].
Light chain and heavy chain CDR residues of bH1 and variants that differ from Herceptin are shown.