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. 2011 Apr 22;6(4):e18133. doi: 10.1371/journal.pone.0018133

Figure 1. N. gonorrhoeae stimulates HIV-1 replication in CD4+ T cells.

Figure 1

HIV-1-infected Jurkat CD4+ T cells (A and C) or T cell receptor crosslinking antibody-activated primary CD4+ T cells (B and D) were co-infected with N. gonorrhoeae at a MOI of 10 (Infected) or left infected with HIV-1 alone (Uninfected) for 5 or 7 days respectively. Subsequently the level of HIV-1 replication was quantified by ELISA for p24 antigen. (A) and (B) represent the mean±s.d. of the actual p24 antigen levels of triplicate wells of one representative experiment. Due to the difficulty in replicating exact HIV-1 infection levels experiment to experiment, (C) and (D) represent the mean±s.e.m. of a minimum of 3 separate experiments with the amount of HIV-1 replication expressed as the percentage of p24 antigen found in bacterial-uninfected samples to allow statistical measurements to be performed. Significant differences are represented by comparison with the following legend: *p≤0.05.