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. 2011 Apr 22;6(4):e18869. doi: 10.1371/journal.pone.0018869

Figure 1. Deletion of SM-Dicer results in a reduction in miRNA expression and weight loss.

Figure 1

Dicer mRNA (A) and selected miRNAs (B and C) were analyzed using RT-qPCR in intact aortas from control (Ctrl) and SM-Dicer KO (KO) mice, 5 or 10 weeks post tamoxifen. Data are mean +SEM, n = 3–6 aortae per group. (D) Mouse weight was measured every 10 days for 9 weeks after tamoxifen treatment in control (Ctrl) and SM-Dicer KO (KO) mice (n = 9–26). (E) Tibia length was measured in KO and Ctrl mice at 5 or 10 weeks post tamoxifen treatment (n = 3–8).