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. 2011 Apr 22;6(4):e19094. doi: 10.1371/journal.pone.0019094

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Pelé et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The barycenters of the SO (red), AMIN (light blue), AD (brown), MEC (pink) and PTG (cyan) sub-families are projected onto the plane formed by the first two components of the human active space. The symbol code indicates the species (N. vectensis: closed diamonds, C. elegans: open circles; C. intestinalis: closed triangles; D. rerio: open diamonds; H. sapiens: closed circles). The color lines joining the barycenters are given for clarity purpose. The pink dashed line indicates the putative phylogenetic relationship between AD and MEC receptors. Transparent circles represent human elements, with color code referring to the GPCR sub-families (AD: brown; AMIN: light blue; CHEM: dark blue; LGR: yellow; MEC: pink; MTN: grey; MRG: violet; OPN: orange; PEP: dark green; PTG: cyan; PUR: light green; SO: red; UC: black).