Figure 4. Effect of PED on food intake and body weight in SV129 and NPY/AgRP-neurons depleted mice.

Food intake (A) and body weight (B) were measured in AgRP^DTR naive mice (circles) and in AgRP^DTR mice treated as pups (squares). Mice were fed from “day 0” on the PED diet. For each point determination, n = 6 mice were studied. At day 6, because AgRP^DTR treated mice still lost weight, PED feeding was stopped and mice were switched back on the control chow diet (SED). Body weight variation (B) is expressed in % of initial body weight and food intake (A) as % of reference food intake, as described in the legend of Fig. 1. All data from day 1 are different from day 0 (Student's t test for paired data) in panel A. *, different from wild-type mice (Student's t test for unpaired data).