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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Brain Behav Immun. 2010 Dec 30;25(4):604–615. doi: 10.1016/j.bbi.2010.12.017

Fig. 1. Maternal IL-6 exposure yields offspring with behavioral abnormalities analogous to those seen in MIA offspring.

Fig. 1

A. Compared to controls, offspring of mice treated with rIL-6 or poly(I:C) display a PPI deficit [F(2, 74)=4.40, *p < 0.05; n=10 saline, 10 poly(I:C), 19 rIL-6 offspring]. B. rIL-6 and poly(I:C) offspring display increased freezing in response to the conditioned acoustic cue during LI testing, as well as decreased LI compared to saline controls when measured against the non-pre-exposed (NPE) group [% freezing = 64.49 ± 6.05 (mean ± SEM)] [F(2, 41)=3.261, *p < 0.05; n=13 saline, 14 poly(I:C), 17 rIL-6 offspring]. NPE poly(I:C) and saline offspring display no significant difference in freezing response. C. Compared to controls, offspring of rIL-6 or poly(I:C)-injected mothers exhibit fewer entries into the center of the open field [F(2, 92)=8.596; p < 0.0005; n=36 saline, 36 poly(I:C), 23 rIL-6 offspring] and shorter duration spent in the center field [F(2, 92)=3.140; *p < 0.05]. rIL-6 offspring also present shorter total distance traveled in the open field [F(2, 92)=12.81; p < 0.0001].