Skip to main content
. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Brain Behav Immun. 2010 Dec 30;25(4):604–615. doi: 10.1016/j.bbi.2010.12.017

Fig. 2. MIA upregulates maternally-derived IL-6 in the placenta.

Fig. 2

A. Compared to controls, placentas from poly(I:C)-injected mothers exhibit increased IL-6 protein at 3, 6 and 24 hours post-injection [n= 9 placentas per treatment per time point (pooled from 3 independent litters); * p < 0.05, ** p < 0.001]. B. At 3 hours post-injection, compared to saline controls, placentas from poly(I:C)-injected mothers also display increased mRNA expression of pro-inflammatory cytokines, including a markedly elevated level of IL-6 [n=9 placentas per treatment group (pooled from 3 independent litters); ***p < 0.0001]. C. Eliminating the contribution of fetally-derived IL-6 has no effect on total placental IL-6 levels, whereas eliminating the contribution of maternally-derived IL-6 completely diminishes total placental IL-6 to levels below those seen in saline controls at both 3 hours and 6 hours post-injection. This indicates that basal and MIA-induced placental IL-6 is maternally-derived. [F(3,80)=24.89; ***p < 0.0001; n= 6-15 placentas per treatment group per genotype pair (pooled from 3-6 litters)].