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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Brain Behav Immun. 2010 Dec 30;25(4):604–615. doi: 10.1016/j.bbi.2010.12.017

Fig. 5. MIA-induced IL-6 action reduces placental IGFI and IGFBP3.

Fig. 5

A. Compared to saline controls, placentas from poly(I:C)-injected mothers have significantly reduced expression of IGFI and IGFBP3 mRNA and a trending decrease in GH expression [n=9 placentas per treatment group (pooled from 3 independent litters); **p < 0.001, # p = 0.24]. B. The deficits in IGFI and IGFBP3 expression observed in MIA placentas require IL-6 production [IGFI: F(2,23)=15.95; *p < 0.05; IGFBP3: F(2,23)=37.77; **p < 0.001; n=8-9 placentas per treatment group (pooled from 3 independent litters]. C. MIA placentas exhibit significantly decreased GH protein [n=7 placentas per treatment group (pooled from 3 independent litters); **p < 0.001]. D. MIA placentas exhibit significantly decreased IGFI protein, and this deficiency is dependent on IL-6 production [F(2, 17)=5.908; *p < 0.05; n=5-7 placentas per treatment group (pooled from 3 independent litters)].