Control (Cont.) or hyperinsulinemic (12h Ins.) cells were treated without or with Cr3+, AICAR, or DON. (A, C) EM cholesterol, (B) pAMPK, and (D) ApoA1-mediated cholesterol efflux. n = 4-11. *P < 0.05 versus untreated control. (E) Model of Cr3+ protection against (Blue) hyperinsulinemia-induced cholesterol-associated impairment in (Red) Rab8/ABCA1 trafficking and ApoA1-mediated cholesterol efflux.