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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Brain Behav Immun. 2011 Feb 18;25(4):787–799. doi: 10.1016/j.bbi.2011.02.007

Fig. 5.

Fig. 5

CGRP8-37 and BIBN4096BS prevent CGRP-induced suppression of CXCL8, CCL2, and CXCL1 expression. (A) CGRP8-37. HMEC-1 cells were stimulated with 10 nM of CGRP in the presence or absence of various concentrations (0–1000 nM) of the CGRP antagonist CGRP8-37 followed by the addition of 1 μg/ml of LPS. Supernatants were collected 48 h later and assayed for chemokine content. (B) BIBN4096BS. This experiment was performed in the same manner except BIBN4096BS (0–1000 nM) was substituted for CGRP8-37. Each result is the mean ± SD of three separate replicates (each with duplicate wells) performed at the same time. This experiment was performed 3 times and the result illustrated by this figure was seen 3 times. (*p<0.05, **p<0.01, ***p<0.001)