Table 1.
Mean ± SEM serum concentrations of morning cortisol (µg/dl) during each of the four treatment conditions in dominant females and subordinate females with an l/l or s-variant 5HTT genotype. Estradiol administration significantly attenuated serum cortisol (p < 0.001), indicated by different numbered superscripts. However, CRHA (corticotropin releasing-hormone receptor analogue) administration significantly increased serum cortisol (p = 0.001), indicated by a different lettered superscript. Serum cortisol did not differ significantly by status, genotype, or their interactions with treatments. See text for details.
Group | Placebo1, A | CRHA1, B | Estradiol2, A | CRHA + Estradiol2, B |
---|---|---|---|---|
Dom, l/l | 27.9 ± 1.8 | 31.9 ± 2.4 | 23.0 ± 2.0 | 30.2 ± 2.3 |
Dom, s-variant | 29.5 ± 2.6 | 34.6 ± 2.9 | 27.4 ± 1.9 | 30.6 ± 2.9 |
Subordinate, l/l | 27.4 ± 1.7 | 32.1 ± 2.3 | 24.7 ± 1.8 | 28.4 ± 2.8 |
Subordinate, s-variant | 28.6 ± 1.4 | 33.0 ± 1.9 | 26.3 ± 1.6 | 32.5 ± 2.4 |