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Expression of patterning genes in Rdh10trex/trex forelimbs. In situ hybridization was used to examine forelimbs in E10.5 wild-type and Rdh10 mutant embryos. (A–B) Fgf8 expression is observed distally in forelimb AER. (C–D) Meis2 expression is seen in the proximal forelimb bud region. (E–F) Shh expression is observed in the posterior/distal region of the forelimb. fl, forelimb bud. Arrowheads mark the relevant expression pattern.
