Table 2.
Examples of immunostimulatory function of myeloid CD11b+Gr-1+ cells
| Function of myeloid CD11b+Gr-1+cells | Experimental model | References | |
|---|---|---|---|
| 1 | Priming and expansion of antigen-specific B cells, optimal production of antibody | Immunization with alum | Jordan et al. 2004 |
| 2 | Inhibition of tumour growth during adoptive immunotherapy with CY | Ehrlich tumour | Peláez et al. 2001 |
| 3 | Activation of NK-cell effector functions | Lymphoma model RMA-S | Nausch et al. 2008 |
| 4 | MDSC-based vaccine increases survival time & protects from metastases | Colon adenocarcinoma | Ko et al. 2009 |
| 5 | Antigen-specific immunity and cross-priming | Ovarian carcinoma model | Tomihara et al. 2010 |
| 6 | CD11b+Ly-6C hi monocytes contributed to tumour growth inhibition | Chronic osteomyelitis in osteosarcoma model | Sottnik et al. 2010 |
| 7 | CD11b+Ly-6C+ cells differentiated into DC that were able to stimulate T cells | Diabetes | Caquard et al. 2010 |
| 8 | Enhancement of CTL response in vitro after differentiation into APC | Mammary adenocarcinoma | Bronte et al. 2000 |
APC, antigen-presenting cell; CTL, cytotoxic T lymphocytes; CY, cyclophosphamide; DC, dendritic cells; MDSC, myeloid-derived suppressor cells; NK, natural killer.