Table 4.
Markers distribution with relation to WHO types
| Markers | Freq (%) (n = 66) | A & AB (n = 24) | B1 & B2 (n = 13) | B3 (n = 17) | Thymic carcinoma (n = 12) | *P-value | |
|---|---|---|---|---|---|---|---|
| CD205 | Negative | 12(18.2) | 9(37.5) | 0(0) | 0(0) | 3(25) | 0.06 |
| Positive | 54(81.8) | 15(62.5) | 13(100) | 17(100) | 9(75) | ||
| FOX1 | Negative | 8(12.1) | 4(16.7) | 1(7.7) | 0(0) | 3(25) | 0.06 |
| Positive | 58(87.9) | 20(83.3) | 12(92.3) | 17(100) | 9(75) | ||
| D2-40 | Negative | 50(75.7) | 18(75) | 10(76.9) | 12(70.6) | 10(83.3) | NS |
| Positive | 16(24.2) | 6(25) | 3(23.1) | 5(29.4) | 2(16.7) | ||
| Calretinin | Negative | 66(100) | 24(100) | 13(100) | 17(100) | 12(100) | NA |
| Positive | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | ||
| WT-1 | Negative | 66(100) | 24(100) | 13(100) | 17(100) | 12(100) | NA |
| Positive | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | ||
| Thrombomodulin | Negative | 62(94) | 22(91.7) | 12(92.3) | 16(94.1) | 12(100) | NS |
| Positive | 4(6.1) | 2(8.3) | 1(7.7) | 1(5.9) | 0(0) | ||
| CK5/6 | Negative | 28(42.4) | 9(37.5) | 8(61.5) | 2(11.7) | 9(75) | 0.001 |
| Positive | 38(57.6) | 15(62.5) | 5(38.5) | 15(88.2) | 3(25) | ||
| HBME | Negative | 61(93.9) | 22(91.7) | 12(100) | 15(88.2) | 12(100) | NS |
| Positive | 4(6.5) | 2(8.3) | 0(0) | 2(11.8) | 0(0) | ||
| Podoplanin | Negative | 59(89.4) | 22(91.7) | 13(100) | 13(76.5) | 11(91.7) | NS |
| Positive | 7(10.6) | 2(8.3) | 0(0) | 4(23.5) | 1(8.3) | ||
| Mesothelin | Negative | 61(92.4) | 24(100) | 13(100) | 17(100) | 7(58.3) | 0.007 |
| Positive | 5(7.6) | 0(0) | 0(0) | 0(0) | 5(41.7) | ||
| p63 | Negative | 1(1.5) | 0(0) | 0(0) | 0(0) | 1(8.3) | NS |
| Positive | 65(98.5) | 24(100) | 13(100) | 17(100) | 11(91.7) | ||
| ER | Negative | 66(100) | 24(100) | 13(100) | 17(100) | 12(100) | NA |
| Positive | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | ||
| PR | Negative | 66(100) | 24(100) | 13(100) | 17(100) | 12(100) | NA |
| Positive | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | ||
| AR (nuclear) | Negative | 65(98.5) | 24(100) | 13(100) | 17(100) | 11(91.7) | NS |
| Positive | 1(1.5) | 0(0) | 0(0) | 0(0) | 1(8.3) | ||
| AR (cytoplasmic) | Negative | 51(77.3) | 23(95.8) | 9(69.2) | 7(41.2) | 12(100) | 0.001 |
| Positive | 15(22.7) | 1(4.2) | 4(30.8) | 10(58.8) | 0(0) | ||
| CD56 | Negative | 66(100) | 24(100) | 13(100) | 17(100) | 12(100) | NA |
| Positive | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | ||
| CD57 | Negative | 40(60.6) | 12(50) | 8(61.5) | 8(47.1) | 12(100) | 0.003 |
| Positive | 26(39.4) | 12(50) | 5(38.5) | 9(52.9) | 0(0) | ||
| CD20 (epithelial) | Negative | 56(84.9) | 16(66.7) | 12(92.3) | 16(94.1) | 12(100) | NS |
| Positive | 10(15.2) | 8(33.3) | 1(7.7) | 1(5.9) | 0(0) | ||
| CD20 (lymphocytic) | Negative | 57(86.4) | 22(91.7) | 8(61.5) | 15(88.2) | 12(100) | NS |
| Positive | 9(13.6) | 2(8.3) | 5(38.5) | 2(11.8) | 0(0) | ||
| CD3 | Negative | 3(5) | 2(10) | 0(0) | 1(6.3) | 0(0) | NS |
| Positive | 57(95) | 18(90) | 13(100) | 15(93.8) | 11(100) | ||
| CD5 | Negative | 57(89.1) | 23(100) | 13(100) | 17(100) | 4(36.4) | 0.0002 |
| Positive | 7(10.9) | 0(0) | 0(0) | 0(0) | 7(63.6) | ||
| TdT | Negative | 22(34.4) | 10(41.7) | 0(0) | 3(17.7) | 9(90) | 0.0007 |
| Positive | 42(65.6) | 14(58.3) | 13(100) | 14(82.4) | 1(10) | ||
| CD1a | Negative | 24(37.5) | 13(54.2) | 0(0) | 3(17.7) | 8(80) | 0.003 |
| Positive | 40(62.5) | 11(45.8) | 13(100) | 14(82.4) | 2(20) | ||
| CD138 | Negative | 23(34.9) | 4(16.7) | 10(76.9) | 6(35.3) | 3(25) | NS |
| Positive | 43(65.2) | 20(83.3) | 3(23.1) | 11(64.7) | 9(75) | ||
| CD117 | Negative | 56(84.9) | 24(100) | 13(100) | 16(94.1) | 3(25) | 0.0001 |
| Positive | 10(15.2) | 0(0) | 0(0) | 1(5.9) | 9(75) | ||
| EMA | Negative | 34(51.5) | 7(29.2) | 12(92.3) | 10(58.8) | 5(41.7) | NS |
| Positive | 32(48.5) | 17(70.8) | 1(7.7) | 7(41.2) | 7(58.3) | ||
| CD15 | Negative | 56(84.9) | 17(70.8) | 13(100) | 15(88.2) | 11(91.7) | NS |
| Positive | 10(15.2) | 7(29.2) | 0(0) | 2(11.8) | 1(8.3) | ||
| MOC31 | Negative | 57(86.4) | 23(95.8) | 13(100) | 15(88.2) | 6(50) | 0.04 |
| Positive | 9(13.6) | 1(4.2) | 0(0) | 2(11.8) | 6(50) | ||
| BerEpi-4 | Negative | 55(83.3) | 19(79.2) | 13(100) | 14(82.4) | 9(75) | NS |
| Positive | 11(16.7) | 5(20.8) | 0(0) | 3(17.7) | 3(25) | ||
| Cyclin D1 | Negative | 26(39.4) | 8(33.3) | 9(69.2) | 7(41.2) | NS | NS |
| Positive | 40(60.6) | 16(66.7) | 4(30.8) | 10(58.8) | 10(83.3) | ||
| p21 | Negative | 50(75.8) | 19(79.2) | 12(92.3) | 15(88.2) | 4(33.3) | 0.005 |
| Positive | 16(24.2) | 5(20.8) | 1(7.7) | 2(11.8) | 8(66.7) | ||
| p27 | Negative | 6(9.1) | 2(8.3) | 1(7.7) | 2(11.8) | 1(8.3) | NS |
| Positive | 60(90.9) | 22(91.7) | 12(92.3) | 15(88.2) | 11(91.7) | ||
| BCL-2 | Negative | 51(72.3) | 14(58.3) | 13(100) | 15(88.2) | 9(75) | NS |
| Positive | 15(27.3) | 10(41.7) | 0(0) | 2(11.8) | 3(25) | ||
| Src | Negative | 5(7.6) | 1(4.2) | 2(15.4) | 2(11.8) | 0(0) | NS |
| Positive | 61(92.4) | 23(95.8) | 11(84.6) | 15(88.2) | 12(100) | ||
| Survivin (nuclear) | Negative | 50(75.8) | 19(79.2) | 8(61.5) | 15(88.2) | 8(66.7) | NS |
| Positive | 16(24.2) | 5(20.8) | 5(38.5) | 2(11.8) | 4(33.3) | ||
| Survivin (cytoplasmic) | Negative | 59(92.2) | 22(95.7) | 13(100) | 17(100) | 7(63.6) | 0.02 |
| Positive | 5(7.81) | 1(4.4) | 0(0) | 0(0) | 4(36.6) | ||
| Ki-67 | Negative | 27(40.9) | 15(62.5) | 2(15.4) | 7(41.2) | 3(25) | NS |
| Positive | 39(59.1) | 9(37.5) | 11(84.6) | 10(58.8) | 9(75) | ||
| p53 | Negative | 27(40.9) | 14(58.3) | 7(53.9) | 5(29.4) | 1(8.3) | NS |
| Positive | 39(59.1) | 10(41.7) | 6(46.2) | 12(70.6) | 11(91.7) | ||
| α-catenin (membranous) | Negative | 32(48.5) | 15(62.5) | 11(84.6) | 4(23.5) | 2(16.7) | NS |
| Positive | 34(51.5) | 9(37.5) | 2(15.4) | 13(76.5) | 10(83.3) | ||
| α-catenin (cytoplasmic) | Negative | 49(74.2) | 19(79.2) | 8(61.5) | 12(70.6) | 10(83.3) | NS |
| Positive | 17(25.8) | 5(20.8) | 5(38.5) | 5(29.4) | 2(16.7) | ||
| β-catenin (membranous) | Negative | 25(37.9) | 10(41.7) | 7(53.9) | 5(29.4) | 3(25) | NS |
| Positive | 41(62.1) | 14(58.3) | 6(46.2) | 12(70.6) | 9(75) | ||
| β-catenin (cytoplasmic) | Negative | 63(95.5) | 22(91.7) | 13(100) | 16(94.1) | 12(100) | NS |
| Positive | 3(4.6) | 2(8.3) | 0(0) | 1(5.9) | 0(0) | ||
| β-catenin (granular) | Negative | 57(86.4) | 21(87.50) | 13(100) | 16(94.1) | 7(58.3) | NS |
| Positive | 9(13.6) | 3(12.5) | 0(0) | 1(5.9) | 5(41.7) | ||
| E-cadherin | Negative | 32(48.5) | 13(54.2) | 6(46.2) | 8(47.1) | 5(41.7) | NS |
| Positive | 34(51.5) | 11(45.8) | 7(53.9) | 9(52.9) | 7(58.3) | ||
| Tumour eosinophilia | Negative | 54(81.8) | 24(100) | 13(100) | 16(94.1) | 1(8.3) | <0.0001 |
| Positive | 12(18.2) | 0(0) | 0(0) | 1(5.9) | 11(91.7) | ||
*
P-value reflects B3 vs. thymic carcinoma