Figure 4.

Selective changes of histone deacetylase transcript levels in the frontal lobes of chronic MS brains. Quantitative RT-PCR of RNA isolated from white matter samples in the frontal cortex of non-neurological controls and MS patients to detect transcript levels of histone deacetylases. The relative levels of expression were first normalized to the transcript levels of the ribosomal protein of the 60S subunit and then expressed as fold changes over the average values calculated in male or female non-neurological controls. The individual values are shown as triangles for females and circles for males. The median value of the ranking distribution is shown by a line.