Figure 5.

The cholate binding site. (a) Amino acid residues within 4.2 Å from the bound cholate (green, carbon; blue, nitrogen; red, oxygen). The side chains of selected residues are shown as gray sticks (gray, carbon; blue, nitrogen; red, oxygen). Residues from the next subunit of CmeR are shown as magenta sticks (magenta, carbon; blue, nitrogen; red, oxygen). (b) Schematic representation of the CmeR and cholate interactions shown in panel a. Dotted lines depict the hydrogen bonds. The hydrogen-bonded distances are also indicated in this figure.