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Summary of the rats used in this study.
| Study | Strain | Treatment | Number | Duration (weeks) |
|---|---|---|---|---|
| Cardiac delivery | SHR | AAV9-Luc | 2 | 3 |
| Toxicology | SHR | Untreated | 3 | 3 |
| SHR | AAV9-Luc | 3 | 3 | |
| SHR | AAV9-BNP | 3 | 3 | |
| Pharmacokinetics/dynamics | SHR | Untreated | 8 | 40 |
| SHR | AAV9-BNP | 8 | 40 | |
| Non-cardiac delivery | SHR | Untreated | 5 | 8 |
| SHR | AAV2-BNP | 5 | 8 | |
| SHR | AAV9-BNP | 3 | 8 | |
| Normotensive rat study | Wistar | AAV9-GFP | 6 | 4 |
| Wistar | AAV9-BNP | 6 | 4 |
SHR, spontaneously hypertensive rats; Luc, luciferase; GFP, green fluorescent protein.
