Table 3.
Prevalence of ART in patients with Beckwith-Wiedemann syndrome.
| Reference Number | Type of study | Number of BWS cases | Prevalence of ART in BWS cohort (cases) | Prevalence of ART in reference population | Type of ART | Association between BWS and ART |
|---|---|---|---|---|---|---|
| 62a | Case series | 65b | 4.6% (3b) | 0.8% | IVF/ICSI | Suggestive |
| 63 | Case series | 149 | 4% (6c) | 1.2% | 3 IVF/3 ICSI | Suggestive |
| 64 | Case series | 149 | 4% (6c) | 1.3% | 4 IVF/2 ICSI | Suggestive |
| 65 | Case-control | 37 | 10.81%d (4) | 0.67%d | 3 IVF/1 ICSI | Suggestive |
| 66a | Case-series | 341 | 5.6%(19) | NA | 5 IVF/5 ICSIe | NA |
| 67 | Survey | 209 | 2.9% (6c) | 0.8% | 1 IVF/5 ICSI | Suggestive |
| 71 | Survey | 71 | 5.6% (4) | 0.92% | IVF/ICSI | Suggestive |
a
Data from the same BWS registry (NCI BWS registry and Washington University BWS registry)
b
Only BWS cohort beginning in 2001 were used to calculate prevalence
c
The frequency of children born after ART in BWS cohort was significantly higher than the expected ART cases based on the ART prevalence in general population
d
Fisher’s exact test, two-sided, P = .006
e
Data on type of ART obtained from 12 patients (2 patients had only ovarian stimulation with intrauterine insemination)