Table 3.

Proportional hazards models comparing the risks of death in modern retransplant recipients (2001–2006), historical retransplant recipients (1990–2000), and modern initial transplant recipients (2001–2006) in the US

	HR	95% CI	p value
Modern lung retransplantation vs. Historical lung retransplantation
Bivariate	0.7	0.5–0.9	0.006
Multivariate*	0.7	0.5–0.97	0.03
Modern lung retransplantation vs. Modern initial lung transplantation
Bivariate	1.3	1.2–1.5	0.001
Multivariate Model 1†	1.2	1.1–1.4	0.003
Multivariate Model 2‡	1.2	1.04–1.3	0.03
Multivariate Model 3§	1.1	1.0–1.3	0.11

^*Adjusted for recipient age, gender, race/ethnicity, initial diagnosis, single/bilateral retransplantation, indication for retransplantation, ischemic time, mechanical ventilation, donor age, race, and mode of death, early retransplantation, diabetes mellitus, and renal failure.

^†Adjusted for recipient age, gender, race/ethnicity, body mass index, initial diagnosis, single/bilateral transplantation, ischemic time, and mechanical ventilation.

^‡Model 1 + adjustment for hypertension, diabetes mellitus, corticosteroid use.

^§Model 2 + adjustment for renal failure.

Data from Kawut SM, Lederer DJ, Keshavjee S, et al. Outcomes after lung retransplantation in the modern era. Am J Respir Crit Care Med. 2008;177(1):114–120.