Table 3. The association of hypertension and cerebral white matter hyperintensities with the risk of being in the impaired group in CHS.

	Unadjusted		Adjusted*
	HR	P-VALUE	HR	P-VALUE
Separate Models
Hypertension (n=3086)	1.55, 95% CI (1.22-1.98)	0.0003	1.29, 95% CI (1.01-1.66)	0.037
WMH grade (n=2325)	1.17, 95% CI (1.1-1.24)	<.0001	1.09, 95% CI (1.02-1.16)	0.007
Combined Models**
Hypertension (n=2325)	1.37, 95% CI (1.05-1.8)	0.0184	1.2, 95% CI (0.91-1.59)	0.19
WMH grade (n=2325)	1.16, 95% CI (1.09-1.24)	<.0001	1.08, 95% CI (1-1.16)	0.04

WMH: Cerebral white matter hyperintensities; HR: Hazard Ratio; CI: Confidence interval

^*Adjusted for: age, gender, ace, education, cigarette smoking, stroke, and total KCALS physical activity (antihypertensives in the WMH model).

^**Combined models include WMH and hypertension in the same model whereas separate model includes only WMH or hypertension. Fit statistics were better for the hypertension model with WMH: Partial Likelihood: 7654 vs 5685; Akaike's information criterion: 7672 vs 5822 and Schwarz Bayesian Criterion : 7711 vs 5705